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Issaiha Seiders was headed north in the left lane of Interstate 83 when he merged right into the center lane, state police said in a release.
As he began to pass a Ford Fusion in the left lane, the Ford merged right, striking Seiders' motorcycle and knocking onto the right shoulder, according to troopers.
Seiders, of Halifax, was pronounced dead at the scene and a passenger on his motorcycle was flown to Hershey Medical Center with serious injuries. The driver of the Ford was not injured, police said.
The crash remains under investigation.
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